CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma
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چکیده
منابع مشابه
CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma.
UNLABELLED Deletion of the entire CDKN2B-CDKN2A gene cluster is among the most common genetic events in cancer. The tumor-promoting effects are generally attributed to loss of CDKN2A-encoded p16 and p14ARF tumor suppressors. The degree to which the associated CDKN2B-encoded p15 loss contributes to human tumorigenesis is unclear. Here, we show that CDKN2B is highly upregulated in benign melanocy...
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ژورنال
عنوان ژورنال: Cancer Discovery
سال: 2015
ISSN: 2159-8274,2159-8290
DOI: 10.1158/2159-8290.cd-15-0196